prevalence of osteoporosis among thalassemia patients from zafar adult thalassemia clinic, iran

نویسندگان

mozhgan hashemieh

azita azarkeivan

mitra radfar

hedieh saneifard

چکیده

background: the advances in treatment regimes for thalassemic patients have increased the survival among them therefore osteoporosis has emerged as an important cause of morbidity. the aim of this study was to determine the prevalence of osteoporosis and osteopenia in patients with thalassemia from zafar adult thalassemia clinic, tehran, iran. patients and methods: in this cross sectional investigation, we studied 239 patients with β thalassemia major and 87 patients with thalassemia intermedia with a mean age of 29±8 years. all demographic data including age, weight, height, sex, age at diagnosis, age at blood transfusion initiation, chelating agent therapy and serum ferritin level were obtained from patients’ history. bone mineral density of the lumbar spine (l1-l4) and femoral neck was determined using dual-energy x-ray absorptiometry (dexa). results: the prevalence of osteoporosis was 65.6% (214 out of 326 patients). osteoporosis was present in 10.7%, 11% and 43.9% of patients in the lumbar spine alone (l1-l4), femoral neck alone and both places, respectively. in the rest of patients 18.7% showed osteopenia and only 15.7% were normal. osteoporosis was more prevalent in patients with thalassemia intermedia compared to thalassemia major (p<0.001). also higher age of patients, longer duration of transfusion and longer intervals between transfusions had a positive correlation with osteoporosis. conclusion: the prevalence of osteoporosis among iranian thalassemia patients is similar to prevalence reported elsewhere. bone mineral density is a good index of bone status in patients with thalassemia and recommended to be done for thalassemic patients annually. key words: thalassemia, bone mineral density, osteoporosis, dexa.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Prevalence of Osteoporosis among Thalassemia Patients from Zafar Adult Thalassemia Clinic, Iran

Background: The advances in treatment regimes for thalassemic patients have increased the survival among them therefore osteoporosis has emerged as an important cause of morbidity. The aim of this study was to determine the prevalence of osteoporosis and osteopenia in patients with thalassemia from Zafar Adult Thalassemia Clinic, Tehran, Iran. Patients and Methods: In this cross sectional inve...

متن کامل

Seroprevalence of HCV antibody among patients with beta-thalassemia major in Amirkola Thalassemia Center, Iran.

beta- thalassemia major is a common hemoglobinopathy in humans. In some journals, numerous studies have reported different prevalence of hepatitis C among beta- thalassemia major because thalassemic patients need multiple blood transfusions and blood transfusion is a common transmission pathway for hepatitis C virus. Thus this study was performed for detection of anti-HCV between beta- thalasse...

متن کامل

Treatment options for thalassemia patients with osteoporosis.

Osteoporosis represents a prominent cause of morbidity in patients with thalassemia. The delay in sexual maturation, the presence of diabetes and hypothyroidism, the parathyroid gland dysfunction, the progressive marrow expansion, the iron toxicity on osteoblasts, the iron chelators, and the deficiency of growth hormone or insulin growth factors have been identified as major causes of osteoporo...

متن کامل

Prevalence of Depression Among Patients With Thalassemia in Southern of Iran

Background: Major thalassemia is known as the most prevalent genetic disorder in Iran. Patients with major thalassemia suffer mostly from psychological problems particularly depression, which can decrease their efficiency in life. Therefore, the present study aimed to explore the prevalence of depression among these patients. Materials and Methods: The present descriptive, cross-sectional resea...

متن کامل

Beta Globin Frameworks in Thalassemia Major Patients from North Iran

OBJECTIVE Four combinations of five neutral sequence changes at rs713040, rs10768683, rs7480526, rs7946748, and rs1609812 occurring in the human beta globin gene defined as frameworks have been reported in beta globin gene. Here we report for the frequency of these frameworks in thalassemia major patients of North Iran. METHODS Beta globin gene frameworks of 46 thalassemia major patients of N...

متن کامل

Torque Teno Virus (TTV) Among β-Thalassemia and Haemodialysis Patients from Mazandaran Province (North of Iran)

Torque Teno virus (TTV) is a transfusion transmitted virus that seems to be involved in several complications such as acute respiratory diseases, liver diseases, AIDS, cancer, and autoimmune reactions.&nbsp; In the present study the frequency of TTV was investigated among &beta;- thalassemia (BT) and haemodialysis (HD) patients (high risk patients for TTV) in Mazandaran province, Iran. DNA was ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of blood and cancer

جلد ۶، شماره ۳، صفحات ۱۴۳-۱۴۸

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023